5 Best Ways To Clean Stains On Mattress: A Complete Guide

Did you know that the average person spends about one-third of their life in bed? While we wash our sheets regularly, we often ignore the mattress underneath. Over time, sweat, spills, and dust mites can leave behind unsightly stains and odors. Sleeping on a dirty mattress is not just unappealing; it can also affect your sleep quality and your health.

Many people feel overwhelmed when they notice a stubborn stain on their bed. You might worry about using harsh chemicals or damaging the expensive fabric of your mattress. Choosing the wrong cleaning method can lead to moisture buildup, which often causes mold and mildew. Because of these fears, many of us simply cover the mess with a mattress pad and try to forget it exists. However, ignoring the problem does not make it go away.

The good news is that you can refresh your bed using simple household items you likely already have in your kitchen. In this post, we will walk you through safe, effective, and easy steps to remove stains without professional help. You will learn how to lift deep spots and sanitize your sleeping surface so you can rest easy again. Let’s dive into the best ways to get your mattress looking and smelling brand new.

Top Way To Clean Stains On Mattress Recommendations

No. 1
Stain Fix Blood Stain Remover for Clothes (8.79oz)- Effectively Clean Fresh & Dried Stains from Clothes, Mattress & Sheets
  • Remove Blood Stain Effectively: Our blood stain remover for clothes works quickly to break down and dissolve blood stains effectively. Say goodbye to frustrating unwashable blood stains.
  • Tackles on Fresh & Old Stains: No need to panic if the blood stain has already set in. This dried blood stain remover is designed to target both fresh and old dried stains for reliable results.
  • Safe for Clothes, Mattress & Sheets: Whether it’s on your favorite shirt, bedding, or even the living room carpet, this blood stain remover gets the job done without damage.
  • Your Safety Net for Accidents: Spills and accidents happen, and that’s okay. Keep this blood stain remover nearby and know you always have a simple way to make things right again.
  • 100% Money Back Guaranteed: We stand by our blood remover for clothes with confidence. If you’re not fully satisfied, return it – no questions asked.
No. 2
Stain Treater Spray, Dry Clean-On-The-Go Spray, Cozy Home Stain Cleaner And Spot Remover​, No Water, No Waiting, Removal Grease, Ink & Wine For Clothes, Shoes, And Fabrics(10.5(Fl Oz))
  • Powerful cleaning: This product features a powerful cleaning formula that leaves clothes feeling clean.
  • Maintains fabric quality: Minimizes damage to clothing, preserving the fabric's original texture and color.
  • Widely applicable: This cleaning spray not only easily tackles common stains but is also suitable for cleaning a variety of fabrics, including clothing and shoes.
  • Easy to use: Simply spray the stain, gently wipe, and watch the stain disappear. No soaking or scrubbing required.
  • Portable design: The leak-proof bottle fits easily into your backpack or diaper bag. It's convenient for use in the office, in the car, or on the go.
No. 3
Stain Venom Foam Multi-Use Laundry and Fabric Stain Remover - 7 oz Bottle - Free From PFAAS, PFOS, PFOA, VOC’s, And 1,4 Dioxane- Works On Fresh Pet Stains, Red Wine, Blood, Lipstick, Motor Oil, Coffee
  • Stain Venom foam cleaner’s fast penetrating formula effectively removes tough stains that include (but not limited to) fresh pet stains, red wine, blood, lipstick, motor oil, coffee, and even mustard. formulated with the latest state-of-the-art technology
  • Stain Venom is an environmentally conscious alternative that contains no solvents, no phosphorus, no VOC’s, no PFAAS, PFOS and PFOA, and no 1,4 Dioxane
  • Stain Venom leaves your fabrics looking clean, soft, and plush. Safe for use in pet areas. Safe for use on water-safe fabrics (W or WS cleaning code)
  • Made in the U.S.A!
No. 4
Absolutely Clean Amazing 60 Second Stain Remover - Powerful, Natural Enzymes Remove Food, Grease, Pet Stains & More, Fast & Easy - Fragrance Free - Eco Friendly - USA Made (16oz Pack of 1)
  • FAST-ACTING FORMULA: Our natural enzyme cleaner formula is incredibly fast acting and does not leave behind greasy, sticky, or filmy residue like other cleaners or soaps. Quickly acts on contact with tough stains and odors, making for a quick and effortless cleaning experience.
  • POWERFUL NATURAL ENZYMES: Absolutely Clean Household 60 Second cleaning supplies uses Powerful, Natural Enzymes to break down odors and stains from dog or cat urine, feces, vomit, bile, blood, drool, red wine, grease, and grass. With Absolutely Clean, you won’t find the noxious fumes given off by other commercial strength cleaners, making for a powerful yet enjoyable cleaning experience.
  • MADE FOR CARPET, UPHOLSTERY & MORE: Our enzyme formula is ideal for cleaning and deodorizing surfaces in your home, car, or RV. It removes odors and stains from all sorts of messes around the house, especially pet messes. You can even use as carpet cleaner, stainless steel cleaner, oven cleaner, spot cleaner, all purpose cleaner, grill cleaner, mattress cleaner and puppy supplies for a thorough cleaning. It’s great for area rugs, floors, furniture, upholstery, and more!
  • VETERINARIAN APPROVED: Our vet-approved enzyme formula is made without the use of harsh chemicals or noxious fumes, making or a gentle yet powerful cleaning solution for removing the toughest stains and eliminating the most stubborn odors.
  • MADE IN THE USA: Absolutely Clean is a small, family owned-and-operated company based in Colorado. We make our products at home in the USA. We believe in providing an exceptional cleaning experience for our customers by providing high-quality products. No matter what your cleaning needs are, Absolutely Clean has the product for you!
No. 5
Queen (13-16 in. Deep) SureGuard Mattress Encasement - 100% Waterproof, Bed Bug Proof, Hypoallergenic - Premium Zippered Six-Sided Cover
  • 100% Waterproof - Six-sided premium mattress protector blocks perspiration, bed wetting, liquids and stains; 10-year quality guarantee (NOTE: For frequent accidents and easy clean-ups, place a fitted SureGuard Mattress Protector over the encasement).
  • Bed Bug Proof - Super fine zipper with Invisi-Zip and SureSeal technology completely seals off the mattress from bed bugs - use with a SureGuard Box Spring Encasement
  • Keeps Your Mattress Clean & Fresh - Blocks dust, dirt and dander on all sides.
  • Soft & Noiseless - 100% cotton terry top; Wicks away moisture; Retains the feel of your mattress - Free from Vinyl, PVC, Phthalates, fire retardants and other toxic chemicals
  • Queen (60 in x 80 in) - Fits 13 to 16 inches deep; Zippered Mattress Encasement - Machine wash and dry. Independently lab tested and GREENGUARD Gold certified.
No. 6
SureGuard Queen Size Mattress Protector - 100% Waterproof, Hypoallergenic - Premium Fitted Cotton Cover - Smooth
  • 100% Waterproof - Top protection against perspiration, bed wetting, liquids and stains; 10-year quality guarantee.
  • Keeps Your Mattress Clean & Fresh - Blocks dust, dirt and dander on the top side.
  • Soft & Noiseless - Smooth pure cotton top surface; Wicks away moisture; Retains the feel of your mattress - Free from Vinyl, PVC, Phthalates, fire retardants and other toxic chemicals
  • Durable & Easy to Clean - Machine wash & dry - For frequent accidents, invest in two or more - while one is washed, the other protects the mattress
  • Queen (60 in x 80 in) - Fitted Sheet Style; Stretchable skirt fits any depth mattress. Independently lab tested and GreenGuard Gold certified.
No. 7
Aemicion Soft King Size Mattress Topper, Luxury Fluffy Cooling Mattress Pad for Back Pain Relief, Easy to Clean, Box Sewing Design, Deep Pockets Fit 8-21" Mattresses 76" x 80"
  • Experience Supreme Softness: Our Soft King Size Mattress Topper is crafted with luxury fluffy 3D silicinized spiral fiber, providing cloud-like comfort that transforms your sleep into a lavish retreat
  • Perfect Fit for Mattresses Securely : Elastic deep pockets fit 8”-21” mattresses, hugging the corners tightly to prevent any slipping or shifting during the night
  • Enhanced Durability & Even Support: The innovative box sewing design securely holds the filling in place, preventing clumping and ensuring the mattress pad maintains its plush, even surface for long-lasting use
  • Machine Washable&Easy Case:The quilted mattress cover are made of high-quality wrinkle and stain resistant fabric, which remains as new after repeated washing. This thick mattress pad can be washed in a large machine with cold water, mild detergent and gentle cycle. Not easy to fade, shrink, or tear. But please don't iron or dry clean
  • Package and Usage Steps: Due to vacuum packaging, it may look thinner after opening the package, please shake and pat it, then make it tumble dry on low heat for 20 minutes, it will restore its shape and thickness
No. 8
SureGuard Twin Extra Long (XL) Mattress Protector - 100% Waterproof, Hypoallergenic - Premium Fitted Cotton Cover - Smooth
  • 100% Waterproof - Top protection against perspiration, bed wetting, liquids and stains; 10-year quality guarantee.
  • Keeps Your Mattress Clean & Fresh - Blocks dust, dirt and dander on the top side.
  • Soft & Noiseless - Smooth pure cotton top surface; Wicks away moisture; Retains the feel of your mattress - Free from Vinyl, PVC, Phthalates, fire retardants and other toxic chemicals
  • Durable & Easy to Clean - Machine wash & dry - For frequent accidents, invest in two or more - while one is washed, the other protects the mattress
  • Twin XL / Dorm bed (39 in x 80 in) - Fitted Sheet Style; Stretchable skirt fits any depth mattress; Invest in two covers for a Split King. Independently lab tested and GreenGuard Gold certified.

The Ultimate Guide to Cleaning Mattress Stains

A clean mattress helps you sleep better. Over time, sweat, spills, and dust build up on your bed. You do not need to buy a new mattress to fix these issues. This guide helps you choose the right tools and methods to refresh your sleeping space.

Key Features to Look For

When shopping for mattress cleaners, look for versatility. A good cleaner works on different types of stains. It should also be safe for the fabric on your mattress. Sprays are often easier to use than powders. Look for a trigger nozzle that sprays a fine mist. This prevents the mattress from getting too wet. Always check if the product is enzyme-based. Enzymes break down organic matter like sweat or pet accidents.

Important Materials

The best cleaners use safe, non-toxic ingredients. Avoid harsh chemicals like bleach. Bleach can damage the foam or fibers inside your mattress. Look for plant-based surfactants or natural enzymes. If you have sensitive skin, choose an unscented formula. Baking soda is also a great material to keep on hand. It absorbs odors and pulls moisture out of the fabric.

Factors That Improve or Reduce Quality

Quality depends on how the cleaner reacts with the stain. A high-quality cleaner lifts the stain to the surface without soaking the inner layers. Excess water is the enemy of a mattress. If a product requires you to soak the bed, it might cause mold or mildew. A fast-drying formula is always better. Avoid cleaners that leave a sticky residue behind. Sticky spots attract more dust and dirt over time.

User Experience and Use Cases

Think about how you will use the cleaner. Do you have a pet that leaves accidents? You need an enzyme cleaner designed for biological stains. Do you just want to refresh a yellowing mattress? A light spray-and-blot cleaner works well. Most users find that gentle scrubbing with a soft brush produces the best results. Always test a small, hidden corner of the mattress first. This ensures the cleaner does not change the color of your fabric.

10 Frequently Asked Questions

Q: How often should I clean my mattress?

A: You should clean your mattress every six months to keep it fresh.

Q: Can I use a steam cleaner on my mattress?

A: It is risky. Too much steam can trap moisture inside and cause mold growth.

Q: What is the best way to remove urine stains?

A: Use an enzyme-based cleaner. It breaks down the proteins in the urine to remove both the stain and the smell.

Q: Does baking soda really work?

A: Yes. Baking soda is excellent for removing odors and absorbing surface oils.

Q: How long does the cleaner take to dry?

A: Most cleaners take about one to two hours. Always let the mattress dry completely before putting sheets back on.

Q: Will cleaning my mattress remove dust mites?

A: Cleaning helps, but you should also use a vacuum with a HEPA filter to remove dust mites effectively.

Q: Can I use dish soap for stains?

A: You can use a tiny drop of dish soap mixed with water. Just make sure you do not get the mattress too wet.

Q: What if the stain is very old?

A: Old stains are harder to remove. You may need to repeat the cleaning process two or three times.

Q: Is it safe to use cleaners on memory foam?

A: Yes, but be very careful. Memory foam absorbs liquid easily. Use the least amount of liquid possible.

Q: How do I know if the mattress is dry?

A: Touch the surface with a dry paper towel. If the towel stays dry, the mattress is ready for the bed sheets.